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Dosage compensation also occurs in fruit ies, and it appears that the gene activity of X chromosome loci is also about equal in males and females. The mechanism is different from that in mammals since no Barr bodies are found in fruit ies. Instead, the male s single X chromosome is hyperactive, approaching the level of transcriptional activity of both of the female s X chromosomes combined. Researchers have discovered a multisubunit protein complex called MSL (for male-speci c lethal) that binds to barcode add in for excel 2010 Excel Add -In for Barcode - Barcode Resource
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The ActiveBarcode Add-In for Excel 2010 or newer is available: using barcodes in Excel has become way easier, faster and powerful. The detailed manual ... hundreds of sites on the single X chromosome in males. Presumably, the binding mediates the hyperactivity of the genes on the X chromosome. (We discuss control of transcription later in the book.) At least ve genes contribute products to this protein complex: msl1, msl2, msl3, mle, and mof. (Mle comes from maleless, and mof comes from males absent on the first.) Along with this protein complex are RNAs that also bind to the male X chromosome. These RNAs, also implicated in dosage compensation, are the products of the rox1 and rox2 genes (for RNA on the X ).Together, the MSL protein complex and the RNAs comprise a compensasome. Mutant alleles of the male-speci c lethal (msl ) genes disrupt dosage compensation in males and are, as their names imply, lethal. However, they appear to have no effect in females. Expression of at least one of these genes, msl2, is repressed by the protein product of the Sxl gene. Thus, sex determination and dosage compensation are 3: The McGraw Hill Companies, 2001 ms excel 2013 barcode font Excel QR - Code , DataMatrix & PDF417 2D Font - IDAutomation
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